Magnetosomes Extracted from Magnetospirillum gryphiswaldense as Theranostic Agents in an Experimental Model of Glioblastoma
نویسندگان
چکیده
منابع مشابه
Large-scale production of magnetosomes by chemostat culture of Magnetospirillum gryphiswaldense at high cell density
BACKGROUND Magnetotactic bacteria have long intrigued researchers because they synthesize intracellular nano-scale (40-100 nm) magnetic particles composed of Fe3O4, termed magnetosomes. Current research focuses on the molecular mechanisms of bacterial magnetosome formation and its practical applications in biotechnology and medicine. Practical applications of magnetosomes are based on their fer...
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Bacterial magnetosomes (BMs) are commonly used as vehicles for certain enzymes, nucleic acids and antibodies, although they have never been considered drug carriers. To evaluate the clinical potential of BMs extracted from Magnetospirillum gryphiswaldense in cancer therapy, doxorubicin (DOX) was loaded onto the purified BMs at a ratio of 0.87 +/- 0.08 mg/mg using glutaraldehyde. The DOX-coupled...
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ژورنال
عنوان ژورنال: Contrast Media & Molecular Imaging
سال: 2018
ISSN: 1555-4309,1555-4317
DOI: 10.1155/2018/2198703